Aliases
14-3-3 protein beta/alpha; 1433B; 143B; KCIP-1; Protein 1054
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P31946
NCBI Gene ID: 7529
Immunogen
Synthesized peptide derived from internal of human 14-3-3 β.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.Leffers H., J. Mol. Biol. 231:982-998(1993).Deloukas P., Nature 414:865-871(2001).Gevaert K., Nat. Biotechnol. 21:566-569(2003).Chi A., J. Proteome Res. 5:3135-3144(2006).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
