Aliases
Protein MIG-5, Tissue inhibitor of metalloproteinases 3, TIMP3
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P35625
Immunogen
Recombinant human Metalloproteinase inhibitor 3 protein (30-208AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Metalloproteinase inhibitor 3 protein
Research
Neuroscience
Literature
[1] “Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.”Uria J.A., Ferrando A.A., Velasco G., Freije J.M., Lopez-Otin C.Cancer Res. 54:2091-2094(1994) [2] “Cloning and characterization of
