Aliases
Factor VII-activating protease, Factor seven-activating protease, FSAP, Hepatocyte growth factor activator-like protein, Plasma hyaluronan-binding protein, HGFAL, PHBP, HABP2
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q14520
Immunogen
Recombinant human Hyaluronan-binding protein 2 protein (314-560AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Cleaves the alpha-chain at multiple sites and the beta-chain between ‘Lys-53’ and ‘Lys-54’ but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Hyaluronan-binding protein 2
Literature
[1]”Marburg I polymorphism of factor VII-activating protease: a prominent risk predictor of carotid stenosis.” Willeit J., Kiechl S., Weimer T., Mair A., Santer P., Wiedermann C.J., Roemisch J. Circulation 107:667-670(2003). [2]”Identification of the substrates for plasma hyaluronan binding protein.” Choi-Miura N.H., Yoda M., Saito K., Takahashi K., Tomita M. Biol. Pharm. Bull. 24:140-143(2001). [3]”The FVII activating protease cleaves single-chain plasminogen activators.” Roemisch J., Vermoehlen S., Feussner A., Stoehr H.-A. Haemostasis 29:292-299(1999).
