Aliases
Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, CTNNG, DP3, JUP
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P14923
Immunogen
Recombinant human Junction plakoglobin protein (1-131AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”Genomic organization and amplification of the human plakoglobin gene (JUP).” Whittock N.V., Eady R.A.J., McGrath J.A.Exp. Dermatol. 9:323-326(2000). [2]”Homo sapiens gamma-catenin mRNA from human KB epidermoid adenocarcinoma cells.”Liang X.-J., Gottesman M.M.Submitted (FEB-2003). [3]”The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”The MGC Project TeamGenome Res. 14:2121-2127(2004).
