Aliases
5DIII, DIOIII, Type 3 DI, Type-III 5′-deiodinase, Dio3, Itdi3, Txdi3
Antibody Type
Polyclonal Antibody
Species
rat
Uniprot ID
P49897
Immunogen
Recombinant rat Type III iodothyronine deiodinase protein (37-278AA)
Raised In
Rabbit
Species Reactivity
rat
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Responsible for the deiodination of T4 (3,5,3′,5′-tetraiodothyronine) into RT3 (3,3′,5′-triiodothyronine) and of T3 (3,5,3′-triiodothyronine) into T2 (3,3′-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Others
Literature
[1]”Genome sequence of the Brown Norway rat yields insights into mammalian evolution.” Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo
