Description
Aliases
L2
Antibody Type
Polyclonal Antibody
Species
Human papillomavirus type 18
Uniprot ID
P06793
Immunogen
Recombinant Human papillomavirus type 18 Minor capsid protein L2 protein (1-462AA)
Raised In
Rabbit
Species Reactivity
Human papillomavirus type 18
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA (By similarity).
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Minor capsid protein L2 protein
Literature
[1]”Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.” Cole S.T., Danos O. J. Mol. Biol. 193:599-608(1987).Additional information
| Size | 50μg, 100μg |
|---|
