Aliases
E2
Antibody Type
Polyclonal Antibody
Species
Human papillomavirus type 18
Uniprot ID
P06790
Immunogen
Recombinant Human papillomavirus type 18 Regulatory protein E2 protein (1-365AA)
Raised In
Rabbit
Species Reactivity
Human papillomavirus type 18
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5′-ACCNNNNNNGGT-3′) present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE’s position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Epigenetics and Nuclear Signaling
Literature
[1]"Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products."Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987). [2]"Ta
