Description
Aliases
Methionine synthase reductase, MSR
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9UBK8
Immunogen
Recombinant human Methionine synthase reductase protein (1-725AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry.”Wolthers K.R., Lou X., Toogood H.S., Leys D., Scrutton N.S.Biochemistry 46:11833-11844(2007). [2]”Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.”Wilson A., Leclerc D., Rosenblatt D.S., Gravel R.A.Hum. Mol. Genet. 8:2009-2016(1999). [3]”Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida.”Doolin M.-T., Barbaux S., McDonnell M., Hoess K., Whitehead A.S., Mitchell L.E.Am. J. Hum. Genet. 71:1222-1226(2002).Additional information
| Size | 50μg, 100μg |
|---|
