Description
Aliases
N-alpha-acetyltransferase 10, N-terminal acetyltransferase complex ARD1 subunit homolog A, NatA catalytic subunit Naa10, NAA10, ARD1, ARD1A, TE2
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P41227
Immunogen
Recombinant human N-alpha-acetyltransferase 10 protein (161-235AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, WB, IHC ;Recommended dilution:WB:1:500-5000, IHC:1:20-1:200
Background / Function
Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency.”Rope A.F., Wang K., Evjenth R., Xing J., Johnston J.J., Swensen J.J., Johnson W.E., Moore B., Huff C.D., Bird L.M., Carey J.C., Opitz J.M., Stevens C.A., Jiang T., Schank C., Fain H.D., Robison R., Dalley B. Lyon G.J. Am. J. Hum. Genet. 89:28-43(2011). [2]A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome.” Esmailpour T., Riazifar H., Liu L., Donkervoort S., Huang V.H., Madaan S., Shoucri B.M., Busch A., Wu J., Towbin A., Chadwick R.B., Sequeira A., Vawter M.P., Sun G., Johnston J.J., Biesecker L.G., Kawaguchi R., Sun H., Kimonis V., Huang T.J. Med. Genet. 51:185-196(2014). [3]System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.”Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.Sci. Signal. 4:RS3-RS3(2011).Additional information
| Size | 50μl, 100μl |
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