Description
Aliases
Tumor suppressor p53-binding protein 1, 53BP1, p53-binding protein 1, p53BP1, TP53BP1
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q12888
Immunogen
Recombinant human Tumor suppressor p53-binding protein 1 protein (1758-1972AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.”Botuyan M.V., Lee J., Ward I.M., Kim J.-E., Thompson J.R., Chen J., Mer G.Cell 127:1361-1373(2006). [2]Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.”Huyen Y., Zgheib O., Ditullio R.A. Jr., Gorgoulis V.G., Zacharatos P., Petty T.J., Sheston E.A., Mellert H.S., Stavridi E.S., Halazonetis T.D.Nature 432:406-411(2004). [3]Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.”Joo W.S., Jeffrey P.D., Cantor S.B., Finnin M.S., Livingston D.M., Pavletich N.P.Genes Dev. 16:583-593(2002).Additional information
| Size | 50μl, 100μl |
|---|
