Description
Aliases
TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q15628
Immunogen
Recombinant human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, WB, IHC ;Recommended dilution:WB:1:500-2000, IHC:1:20-1:200
Background / Function
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.”Park Y.C., Ye H., Hsia C., Segal D., Rich R.L., Liou H.C., Myszka D.G., Wu H. Cell 101:777-787(2000). [2]Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway.” Tsao D.H., McDonagh T., Telliez J.-B., Hsu S., Malakian K., Xu G.Y., Lin L.L.Mol. Cell 5:1051-1057(2000). [3]Initial characterization of the human central proteome.”Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011).Additional information
| Size | 50μl, 100μl, 50μg, 100μg |
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