Caspase 2, Human Recombinant

Description

Caspase 2, Human Recombinant

General description

Caspase-2 (also known as Ich-1, Nedd-2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, Caspase-2 also exists in cells as an inactive proenzyme. During apoptosis pro-caspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed active Caspase-2 is a heterotetrametric molecule consisting of two large (19 kDa) and two small (12 kDa) subunits. The recombinant active human Caspase-2 was expressed in E. coli. The active Caspase-2 preferentially cleaves Caspase-2 substrates (e.g., VDVAD-AFC or VDVAD-pNA).

Synonyms:                        Caspase-2, CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1

Gene Symbol:                   CASP2

Gene ID:                             835

Source:                               E. coli.

Form:                                  Lyophilized powder

Molecular Weight:            Two large (19 kDa) and two small (12 kDa) subunit

Reconstitution Inst.:         Reconstitute to 1 unit per µl in PBS containing 15% glycerol

Handling:                           Centrifuge the vial prior to opening

Storage temp.:                 -70°C

Additional information