Aliases
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
Antibody Type
Polyclonal Antibody
Uniprot ID
Q14241
Immunogen
Synthetic peptide of human TCEB3
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA: 1:2000-1:5000; IHC: 1:25-1:100
Background / Function
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen affinity purification
