Aliases
EC 3.4.22.-; FKSG6; KIAA0797; Protease FKSG6; SEN6
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q9GZR1
NCBI Gene ID: 26054
Immunogen
Synthesized peptide derived from Internal of human SENP6.
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
IHC Recommended dilution: Immunohistochemistry: 1:50~1:100
Background / Function
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.Dong Chen, Blood (ASH Annual Meeting Abstracts), Nov 2005; 106: 4188.Debaditya Mukhopadhyay, J. Cell Biol., Sep 2006; 174: 939 – 949. Jinke Cheng, Mol. Cell. Biol., Jul 2004; 24: 6021 – 6028. Marius C. Jones, PNAS, Oct 2006; 103: 16272 – 16277.
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
