Aliases
RNA polymerase II elongation factor ELL; RNA polymerase II elongation factor ELL; ELL; C19orf17;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P55199
NCBI Gene ID: 8178
Immunogen
Synthesized peptide derived from internal of human ELL.
Raised In
Rabbit
Species Reactivity
Human Mouse
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.Thirman M.J., Proc. Natl. Acad. Sci. U.S.A. 91:12110-12114(1994).Simone F., Blood 98:201-209(2001).Kong S.E., Proc. Natl. Acad. Sci. U.S.A. 102:10094-10098(2005).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
