Aliases
Macrophage erythroblast attacher; Erythroblast macrophage protein; Cell proliferation-inducing gene 5 protein; Lung cancer-related protein 10; HLC-10
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q7L5Y9
NCBI Gene ID: 10296
Immunogen
Synthesized peptide derived from internal of human MAEA.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.Ota T., Nat. Genet. 36:40-45(2004).Hanspal M., Blood 92:2940-2950(1998).Bala S., Biochem. Biophys. Res. Commun. 342:1040-1048(2006).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
