Aliases
ANAPC1; ANC1; Anaphase promoting complex subunit 1; Cyclosome subunit 1; Mitotic checkpoint regulator
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q9H1A4
NCBI Gene ID: 64682
Immunogen
Synthesized peptide derived from internal of human Cyclosome 1.
Raised In
Rabbit
Species Reactivity
Human Mouse
Tested Applications
IF Recommended dilution: Immunofluorescence: 1:100~1:500
Background / Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of ‘Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ‘Lys-48’- and ‘Lys-63’-linked polyubiquitin chains.Joergensen P.M., Gene 262:51-59(2001).Ota T., Nat. Genet. 36:40-45(2004).Kraft C., EMBO J. 22:6598-6609(2003).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
