Aliases
CAR; Coxsackievirus and adenovirus receptor precursor; Coxsackievirus B- adenovirus receptor; CVB3 binding protein; CXAR
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P78310
NCBI Gene ID: 1525
Immunogen
Synthesized peptide derived from internal of human CXADR.
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.Tomko R.P., Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997).Bergelson J.M., Science 275:1320-1323(1997).Bowles K.R., Hum. Genet. 105:354-359(1999).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
