Aliases
ach10; cholinergic receptor; nicotinic; alpha 10; chrna10
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q9GZZ6
NCBI Gene ID: 57053
Immunogen
Synthesized peptide derived from C-terminal of human CHRNA10.
Raised In
Rabbit
Species Reactivity
Human Mouse
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.Sgard F., Mol. Pharmacol. 61:150-159(2002).Lustig L.R., Genomics 73:272-283(2001).Vandenberk I., Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
