Aliases
Receptor tyrosine-protein kinase ErbB-1; ERBB1;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P00533
NCBI Protein: NP_005219.2
Immunogen
Peptide sequence around aa.867~871 (K-E-Y-H-A) derived from Human EGFR.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB IHC Recommended dilution: Predicted MW: 175kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100,
Background / Function
Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiaGingras AC, et al. (1998) Genes Dev 12(4): 502-513.Brugarolas J, et al. (2004) Genes Dev 18(23): 2893-2904.Kumar V, et al. (2000) EMBO J 19(5): 1087-1097.Moody CA, et al. (2005) J Virol 79(9): 5499-5506.Burnett PE, et al. (1998) Proc Natl Acad Sci U S A 95(4): 1432-1437.
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
