Aliases
Angiopoietin-related protein 3, FHBL2, ANGPT5
Antibody Type
Polyclonal Antibody
Uniprot ID
Genbank No.: BC058287
Immunogen
Fusion protein corresponding to C terminal 300 amino acids of Human Angiopoietin-related protein 3
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
ELISA WB IHC Recommended dilution: Predicted MW: 54kd, ELISA: 1:1000-1:5000, Western blotting: 1:500-1:2000, Immunohistochemistry: 1:25-1:100
Background / Function
The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
Conjugate
Unconjugated
Storage Buffer
Supplied at 0.8mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
