Aliases
baculoviral IAP repeat containing 7, KIAP, LIVIN, MLIAP, RNF50, ML-IAP
Antibody Type
Polyclonal Antibody
Uniprot ID
Genbank No.: BC014475
Immunogen
Full length fusion protein
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
ELISA WB IHC Recommended dilution: Predicted MW: 33kd , ELISA: 1:2000-1:5000, Western blotting: 1:500-1:2000, Immunohistochemistry: 1:10-1:50
Background / Function
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
Conjugate
Unconjugated
Storage Buffer
Supplied at 0.6mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
