Aliases
matrix metallopeptidase 8 (neutrophil collagenase), HNC, CLG1, MMP-8, PMNL-CL
Antibody Type
Polyclonal Antibody
Uniprot ID
Genbank No.: NP_002415
Immunogen
Synthetic peptide corresponding to a region derived from 122-135 amino acids of human matrix metallopeptidase 8 (neutrophil collagenase)
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
ELISA WB IHC Recommended dilution: Predicted MW: 53kd, ELISA: 1:2000-1:5000, Western blotting: 1:500-1:2000, Immunohistochemistry: 1:25-1:100
Background / Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.6mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
