Aliases
Thioredoxin, TRX; TRDX; TRX1
Antibody Type
Polyclonal Antibody
Uniprot ID
Genbank No.: NP_003320
Immunogen
Synthetic peptide corresponding to a region derived from 90-105 amino acids of human thioredoxin
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
ELISA WB IHC Recommended dilution: Predicted MW: 12kd , ELISA: 1:2000-1:10000, Western blotting: 1:1000-1:5000, Immunohistochemistry: 1:50-1:200
Background / Function
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.2mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
