Aliases
Gp80-LNGFR; NGF receptor; TNFRSF16; TNR16; low affinity neurotrophin receptor p75NTR
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P08138
NCBI Gene ID: 4804
Immunogen
Synthesized peptide derived from internal of human TNR16.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB IF Recommended dilution: Western blotting: 1:500~1:3000Immunofluorescence: 1:100~1:500
Background / Function
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake By similarity. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.Ye X., J. Biol. Chem. 274:30202-30208(1999).Wooten M.W., J. Biol. Chem. 276:7709-7712(2001).Bai D., Biochem. Biophys. Res. Commun. 309:552-557(2003).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
