Aliases
C1orf16; EST1C; KIAA0250;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q92540
NCBI Gene ID: 9887
Immunogen
Synthesized peptide derived from internal of human SMG7.
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
WB IF Recommended dilution: Western blotting: 1:500~1:3000Immunofluorescence: 1:100~1:500
Background / Function
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.Ohnishi T., Mol. Cell 12:1187-1200(2003).Nagase T., DNA Res. 3:321-329(1996).Nakajima D., DNA Res. 9:99-106(2002).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
