Aliases
SYUB; beta-synuclein;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q16143
NCBI Gene ID: 6620
Immunogen
Synthesized peptide derived from human Synuclein β antibody.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB IHC IF Recommended dilution: Western blotting: 1:500~1:3000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:500
Background / Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.Yuxin Fan, Hum. Mol. Genet., Oct 2006; 15: 3002 – 3011. Makoto Hashimoto, J. Biol. Chem., May 2004; 279: 23622 – 23629. Cristine Alves da Costa, J. Biol. Chem., Sep 2003; 278: 37330 – 37335. Heather Snyder, J. Biol. Chem., Mar 2005; 280: 7562 – 7569.
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
