Description
Aliases
TRKA; TRK; NTRK1; p140-TrkA;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot#: P04629;
NCBI Gene#: 4914;
N
Immunogen
Peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y(p)-L-D) derived from Human Trk A.
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
IHC Recommended dilution: Immunohistochemistry: 1:50~1:100
Background / Function
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Tina Garofalo, J. Biol. Chem., Dec 1998; 273: 35153.Jan Grimm, J. Cell Biol., Jul 2001; 154: 345.Jose L. Tomsig, J Androl, May 2006; 27: 348 – 357.VI Shifrin and BG Neel J. Biol. Chem., Dec 1993; 268: 25376 – 25384
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Modification
Phospho-Tyr791
Additional information
| Size | 100?l |
|---|
