Aliases
HTATIP; TI60; Tat-interactive protein-60;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot#: Q92993;
NCBI Gene#: 10524;
Immunogen
Peptide sequence around phosphorylation site of Serine 90(P-G-S(p)-P-E) derived from Human Tip60.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
IHC Recommended dilution: Immunohistochemistry: 1:50~1:100
Background / Function
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.Kamine J., Virology 216:357-366(1996).Sheridan A.M., Mol. Cell. Biol. 21:4470-4481(2001).Legube G., Gene 310:161-168(2003).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Modification
Phospho-Ser90
