Description
Aliases
Major centromere autoantigen B, Centromere protein B, CENP-B, CENPB
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P07199
Immunogen
Recombinant human Major centromere autoantigen B protein (1-165AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”The MGC Project TeamGenome Res. 14:2121-2127(2004). [2]”Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.”Orthaus S., Biskup C., Hoffmann B., Hoischen C., Ohndorf S., Benndorf K., Diekmann S.ChemBioChem 9:77-92(2008). [3]”Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.”Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. IIIJ. Proteome Res. 7:1346-1351(2008).Additional information
| Size | 50μg, 100μg |
|---|
