Description
Aliases
Bcl2, Bcl-2
Antibody Type
Polyclonal Antibody
Species
Mouse
Uniprot ID
P10417
Immunogen
Recombinant mouse Apoptosis regulator Bcl-2 protein (5-205AA)
Raised In
Rabbit
Species Reactivity
Mouse
Tested Applications
ELISA, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Others
Literature
[1] "Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma."Negrini M., Silini E., Kozak C., Tsujimoto Y., Croce C.M.Cell 49:455-463(1987) [2] "IsolationAdditional information
| Size | 50μg, 100μg |
|---|
