Description
Aliases
Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, BMPR1A, ACVRLK3, ALK3
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P36894
Immunogen
Recombinant human Bone morphogenetic protein receptor type-1A protein (177-532AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”The MGC Project TeamGenome Res. 14:2121-2127(2004). [2]”Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties.”Mahlawat P., Ilangovan U., Biswas T., Sun L.Z., Hinck A.P.Biochemistry 51:6328-6341(2012). [3]”Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.”Howe J.R., Bair J.L., Sayed M.G., Anderson M.E., Mitros F.A., Petersen G.M., Velculescu V.E., Traverso G., Vogelstein B.Nat. Genet. 28:184-187(2001).Additional information
| Size | 50μg, 100μg |
|---|
