Description
Aliases
Intrinsic factor, IF, INF, IFMH, GIF
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P27352
Immunogen
Recombinant human Gastric intrinsic factor protein (19-417AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene.” Tanner S.M., Li Z., Perko J.D., Oener C., Cetin M., Altay C., Yurtsever Z., David K.L., Faivre L., Ismail E.A., Graesbeck R., de la Chapelle A. Proc. Natl. Acad. Sci. U.S.A. 102:4130-4133(2005). [2]”A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency.” Gordon M.M., Brada N., Remacha A., Badell I., del Rio E., Baiget M., Santer R., Quadros E.V., Rothenberg S.P., Alpers D.H. Hum. Mutat. 23:85-91(2004). [3]”Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.”Andersen C.B., Madsen M., Storm T., Moestrup S.K., Andersen G.R. Nature 464:445-448(2010).Additional information
| Size | 50μg, 100μg |
|---|
