ADAM10 Antibody, HRP conjugated

$231.52$415.64

Description

Aliases

Disintegrin and metalloproteinase domain-containing protein 10 (EC:3.4.24.81), ADAM 10, ADAM10, KUZ, MADM, CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD_antigen: CD156c

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

O14672

Immunogen

Recombinant human Disintegrin and metalloproteinase domain-containing protein 10 protein (214-504AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77′ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Additional information

Size

50μg, 100μg

Certificate of Analysis