Aliases
AGRT, ART, AGRP
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O00253
Immunogen
Recombinant human Agouti-related protein (83-132AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Agouti-related
Literature
[1]”Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness.” de Rijke C.E., Jackson P.J., Garner K.M., van Rozen R.J., Douglas N.R., Kas M.J., Millhauser G.L., Adan R.A. Biochem. Pharmacol. 70:308-316(2005). [2]”A polymorphism in the human agouti-related protein is associated with late-onset obesity.” Argyropoulos G., Rankinen T., Neufeld D.R., Rice T., Province M.A., Leon A.S., Skinner J.S., Wilmore J.H., Rao D.C., Bouchard C. J. Clin. Endocrinol. Metab. 87:4198-4202(2002). [3]”Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity.” Jackson P.J., McNulty J.C., Yang Y.K., Thompson D.A., Chai B., Gantz I., Barsh G.S., Millhauser G.L. Biochemistry 41:7565-7572(2002).
