Description
Aliases
onized calcium-binding adapter molecule 1, Iba1, Aif1
Antibody Type
Polyclonal Antibody
Species
Mouse
Uniprot ID
O70200
Immunogen
Recombinant mouse Allograft inflammatory factor 1 protein (2-147AA)
Raised In
Rabbit
Species Reactivity
Mouse
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Allograft inflammatory factor 1
Literature
[1]”X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding.” Yamada M., Ohsawa K., Imai Y., Kohsaka S., Kamitori S. J. Mol. Biol. 364:449-457(2006) . [2]”Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity.” Ohsawa K., Imai Y., Sasaki Y., Kohsaka S. J. Neurochem. 88:844-856(2004) . [3]”Iba1 is an actin-cross-linking protein in macrophages/microglia.” Sasaki Y., Ohsawa K., Kanazawa H., Kohsaka S., Imai Y. Biochem. Biophys. Res. Commun. 286:292-297(2001).Additional information
| Size | 50μg, 100μg |
|---|
