Aliases
ALX homeobox 4, FND2
Antibody Type
Polyclonal Antibody
Uniprot ID
Genbank No.: NP_068745
Immunogen
Synthetic peptide corresponding to a region derived from 27-45 amino acids of Human ALX homeobox 4
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
ELISA WB Recommended dilution: Predicted MW: 44kd , ELISA: 1:1000-1:5000, Western blotting: 1:500-1:1000
Background / Function
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.
Conjugate
Unconjugated
Storage Buffer
Supplied at 0.4mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
