Aliases
Histone chaperone ASF1A; Anti-silencing function protein 1 homolog A; hAsf1; hAsf1a; CCG1-interacting factor A
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q9Y294
NCBI Gene ID: 25842
Immunogen
Synthesized peptide derived from internal of human ASF1A.
Raised In
Rabbit
Species Reactivity
Human Mouse
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.Munakata T., Genes Cells 5:221-233(2000).Sillje H.H.W., Curr. Biol. 11:1068-1073(2001).Lai C.-H., Genome Res. 10:703-713(2000).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
