Description
Aliases
Apoptosis inhibitor 4, Apoptosis inhibitor survivin, TIAP, Api4, Iap4, Birc5
Antibody Type
Polyclonal Antibody
Species
Mouse
Uniprot ID
O70201
Immunogen
Recombinant mouse Baculoviral IAP repeat-containing protein 5 protein (1-140AA)
Raised In
Rabbit
Species Reactivity
Mouse
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin. Muchmore S.W., Chen J., Jakob C., Zakula D., Matayoshi E.D., Wu W., Zhang H., Li F., Ng S.C., Altieri D.C. Mol. Cell 6:173-182(2000). [2]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project Team Genome Res. 14:2121-2127(2004). [3]Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions. Conway E.M., Pollefeyt S., Cornelissen J., DeBaere I., Steiner-Mosonyi M., Ong K., Baens M., Collen D., Schuh A.C. Blood 95:1435-1442(2000).Additional information
| Size | 50μg, 100μg |
|---|
