BMPR1A Antibody, HRP conjugated

$231.52$415.64

Description

Aliases

Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, BMPR1A, ACVRLK3, ALK3

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P36894

Immunogen

Recombinant human Bone morphogenetic protein receptor type-1A protein (177-532AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”The MGC Project TeamGenome Res. 14:2121-2127(2004). [2]”Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties.”Mahlawat P., Ilangovan U., Biswas T., Sun L.Z., Hinck A.P.Biochemistry 51:6328-6341(2012). [3]”Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.”Howe J.R., Bair J.L., Sayed M.G., Anderson M.E., Mitros F.A., Petersen G.M., Velculescu V.E., Traverso G., Vogelstein B.Nat. Genet. 28:184-187(2001).

Additional information

Size

50μg, 100μg

Certificate of Analysis