Caspase 7, Human Recombinant
General description
Caspase-7 (also known as Mch3, ICE-LAP3, CMH-1) is a member of the caspase-family of cysteine proteases. Similar to other caspases, Caspase-7 also exists in cells as an inactive proenzyme. During apoptosis procaspase-7 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of Caspase-7 consists of large and small subunits which associate to form the active enzyme. Active Caspase-7 has been shown to be of importance in the proteolysis of PARP (poly ADP-ribose polymerase), an enzyme that is involved in DNA repair and genomic maintenance. The recombinant active human Caspase-7 was expressed in E. coli.
Synonyms:Â Â Â Â Â Â Â Â Â Â Â Â Caspase-7, CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3
Gene Symbol:Â Â Â Â Â Â Â Â Â CASP7
Gene ID:Â Â Â Â Â Â Â Â Â Â Â Â Â Â 840
Source:Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â E. coli.
Form:Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Lyophilized powder
Reconstitution Inst.:      Reconstitute to 1 unit per µl in water
Handling:Â Â Â Â Â Â Â Â Â Â Â Â Â Centrifuge the vial prior to opening
Storage temp.:         -70°C
