Caspase 8, Human Recombinant
General description
Caspase-8 (also known as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases. Similar to other caspases, Caspase-8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of Caspase-8 consists of large and small subunits which associate to form the active enzyme. Active Caspase-8 has been shown to activate Caspase-3 leading to degradation of a variety of cellular target proteins during apoptosis. The recombinant active human Caspase-8 was expressed in E. coli.
Synonyms:Â Â Â Â Â Â Â Â Â Â Â Â Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog
Gene Symbol:Â Â Â Â Â Â Â Â Â CASP8
Gene ID:Â Â Â Â Â Â Â Â Â Â Â Â Â Â 841
Source:Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â E. coli.
Form:Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Lyophilized powder
Reconstitution Inst.:      Reconstitute to 1 unit per µl in PBS containing 15% glycerol
Handling:Â Â Â Â Â Â Â Â Â Â Â Â Â Centrifuge the vial prior to opening
Storage temp.:         -70°C
