Aliases
CKR5; CD195; CKR-5
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P51681
NCBI Protein: NP_000570.1
Immunogen
Peptide sequence around aa.11~15(D-I-N-Y-Y) derived from Human CCR5(CD195).
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
WB Recommended dilution: Predicted MW: 41kd, Western blotting: 1:500~1:1000,
Background / Function
Receptor for a number of inflammatory CC-chemokines including MIP-1-a, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.Samson M., Labbe O., Mollereau C. Biochemistry 35:3362-3367(1996)Raport C.J., Gosling J., Schweichart V.L. J. Biol. Chem. 271:17161-17166(1996) Combadiere C., Ahuja S.K., Tiffany H.L., Murphy P.M.J. Leukoc. Biol. 60:147-152(1996)
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
