General Description
A non denaturing zwitterionic detergent with characteristics similar to CHAPS, although more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins. CHAPSO has been used in a study to assess the processes of liposome solubilization and reconstitution of two transport proteins. It has also been used in a study to investigate a novel bicelle system for orienting macromolecules over a wide temperature range. It can be used for solubilization of membrane proteins. Both CHAPS and CHAPSO have a low light absorbance in the ultraviolet region of the electromagnetic spectrum, which is useful for monitoring ongoing chemical reactions or protein-protein binding with UV/Vis spectroscopy.
CAS Number:Â Â Â Â Â Â Â Â Â Â 82473-24-3;
Synonyms:Â Â Â Â Â Â Â Â Â Â Â Â MFCD00081079; CHAPS Hydroxy analog; BioXtra; AC1L3U2M; 3-((3-Cholamidopropyl)dimethylammonio)-2-hydroxy-1-propanesulfonate;
Molecular Formula:Â Â Â Â C32H58N2O8S
Molecular Weight:Â Â Â Â Â Â 630.882 g/mol (anhydrous basis)
InChI Key:Â Â Â Â Â Â Â Â Â Â Â Â Â GUQQBLRVXOUDTN-XOHPMCGNSA-N
