Aliases
ciliary neurotrophic factor receptor
Antibody Type
Polyclonal Antibody
Uniprot ID
Genbank No.: BC001492
Immunogen
Fusion protein corresponding to a region derived from 23-342 amino acids of human ciliary neurotrophic factor receptor
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
ELISA WB Recommended dilution: Predicted MW: 41kd, ELISA: 1:1000-1:5000, Western blotting: 1:500-1:2000
Background / Function
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
Conjugate
Unconjugated
Storage Buffer
Supplied at 0.5mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
