Aliases
PHLL1
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q16526
NCBI Protein: NP_031797.1
Immunogen
Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1.
Raised In
Rabbit
Species Reactivity
Mouse
Tested Applications
WB Recommended dilution: Predicted MW: 60kd, Western blotting: 1:500~1:1000
Background / Function
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45. Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8. Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
