Aliases
FBX1; FBXO1; F-box only protein 1;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P41002
NCBI Gene ID: 899
Immunogen
Synthesized peptide derived from human Cyclin F.
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
WB IHC Recommended dilution: Western blotting: 1:500~1:3000, Immunohistochemistry: 1:50~1:100,
Background / Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.Tsz Kan Fung, J. Biol. Chem., Sep 2002; 277: 35140 – 35149.Michael T. Tetzlaff, Mol. Cell. Biol., Mar 2004; 24: 2487 – 2498.Cain H. Yam, Mol. Cell. Biol., Jan 1999; 19: 635 – 645.Michael T. Tetzlaff, PNAS, Mar 2004; 101: 3338 – 3345.
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
