Aliases
DCUN1 domain-containing protein 1, Defective in cullin neddylation protein 1-like protein 1, Squamous cell carcinoma-related oncogene, DCUN1L1, RP42, SCCRO, DCUN1D1
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q96GG9
Immunogen
Recombinant human DCN1-like protein 1 protein (1-259AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]Initial characterization of the human central proteome. Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011). [2]SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. Kim A.Y., Bommelje C.C., Lee B.E., Yonekawa Y., Choi L., Morris L.G., Huang G., Kaufman A., Ryan R.J., Hao B., Ramanathan Y., Singh B. J. Biol. Chem. 283:33211-33220(2008). [3]Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. Jacques C., Baris O., Prunier-Mirebeau D., Savagner F., Rodien P., Rohmer V., Franc B., Guyetant S., Malthiery Y., Reynier P. J. Clin. Endocrinol. Metab. 90:2314-2320(2005).
