Description
Aliases
DIS3-like exonuclease 2UniRule annotation, DIS3L2
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q8IYB7
Immunogen
Recombinant human DIS3-like exonuclease 2 protein (201-400AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC;Not yet tested in other applications.
Background / Function
3′-5′-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3′ end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3′. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Additional information
| Size | 50μg, 100μg |
|---|
