Aliases
dysferlin; limb girdle muscular dystrophy 2B (autosomal recessive);
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: O75923
NCBI Gene ID: 8291
Immunogen
Synthesized peptide derived from human Dysferlin.
Raised In
Rabbit
Species Reactivity
Human Mouse
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Key calcium ion sensor involved in the Ca2+-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress By similarity.Delia J. Hern篓顣攄ez-Deviez, Hum. Mol. Genet., Jan 2006; 15: 129 – 142. Yanchao Huang, FASEB J, Mar 2007; 21: 732 – 742.Mengfatt Ho, Hum. Mol. Genet., Sep 2004; 13: 1999 – 2010.Eriko Fujita, Hum. Mol. Genet., Mar 2007; 16: 618 – 629.
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
